HealthTalk: Tuberculosis: Can be fatal if not treated

By Johannes Marisa | May. 26, 2024

A healthy immune system often successfully fights TB bacteria.

I get troubled when I see patients dying of tuberculosis, a disease that is treated for free in our country.

Tuberculosis, commonly known as TB, is one of the top 10 causes of death worldwide.

In 2018, WHO estimated that 10 million people fell ill with TB and 1,5 million died from the disease, majority of whom are from Africa, south of the Sahara.

Over the last five years, the number of TB cases detected annually in Zimbabwe has ranged between 40 000 and 50 000. A lot of other cases are not diagnosed till death.

TB is a potentially serious infectious disease that mainly affects your lungs. The bacteria that cause TB are spread from one person to another through tiny droplets released into the air via coughs and sneezes.

Bacterium is usually Mycobacterium Tuberculosis although Mycobacterium Bovis, Avium Intracellulae used to be implicated in some cases.

Other than the lungs, TB can affect the spine, joints, lymph nodes, brain, the liver, kidneys, heart or even the skin.

Symptoms

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Although your body can harbour bacteria that cause TB, your immune system can protect you from sickness. It is thus imperative that a distinction is made between:

Latent TB — Here there is TB infection but bacteria remain in your body in an inactive state and cause no symptoms. Latent TB is not contagious but can turn into active TB.
Active TB — This makes you sick and in most cases can spread to others. It can occur in the first few weeks after infection with TB bacteria or might occur years later.

Therefore, signs and symptoms of active TB include:

Chronic cough (usually lasts 3 or more weeks)
Coughing up blood
Drenching night sweats
Unintentional weight loss
Chest pains with breathing or coughing
Loss of appetite
Non-remitting fever
Fatigue

*NB Do not prescribe for yourself cough mixtures if such symptoms are present, instead, visit your doctor. We do not want to lose lives!

Please note that TB can affect any part of the body and some symptoms can appear depending on what is affected.

One can have TB Spine, TB Meningitis, TB Adenitis, TB of the Kidneys, TB of the Heart etc.

Risk factors

A healthy immune system often successfully fights TB bacteria.

However, there are some conditions that predispose one to TB infection. It is unfortunate that about 30% of all HIV-related deaths come from TB alone.

Lately in Africa, more than 80% of all TB cases have been linked to HIV/AIDS meaning less than 20% of all those who have TB are HIV negative.

Other immune suppressants that predispose to TB are:

Diabetes
Certain cancers
Cancer treatment such as chemotherapy
Malnutrition like Kwashiorkor, Marasmus
The very young ages or advanced ages
Severe kidney disease

n Drugs to prevent rejection of transplanted organs

Diagnosis

Diagnosis comes from a combination of physical examination and tests. Examination finds such things as enlarged lymph nodes (mutochera) in such areas as the arm pits or the neck. Wasting of the body will be noted associated with a troublesome fever

Sputum tests — Usually three bottles are given to patients to put sputum inside so that TB bacteria can be looked for.
This analysis is done by laboratory scientists. However, about 40% of TB bacteria can be missed from the sputum, giving a false negative answer. This is a serious cause for concern for some clinics and hospitals that have denied some patients treatment basing on sputum results.
Clinical correlation should be done. Some council hospitals in Harare have been rejecting patients referred by doctors with obvious clinical TB and evident X-Rays citing sputum negativity.
Genexpert test — This is a molecular TB test, which detects the presence of TB bacteria in the sputum, as well as testing for resistance to Rifampicin. This technology was launched in 2004.
X-rays — Chest X-rays can show consolidation, cavitation or effusion which ought to be clinically correlated with symptoms. Please encourage your patients to go for X-rays.
Biopsy — Masses or lumps can be removed for histology

Prevention and Treatment

Prevent contracting TB by observing some of the following:

Get early HIV screening and treatment
Get routine screening at high risk work places like mines
Stay in well-ventilated houses
Finish your entire course of TB treatment to avoid a relapse
Be sure your child is immunised at birth by getting Bacille Calmette Guerin (BCG).

Treatment

Treatment is a minimum of six months where combination tablets are taken. It is sad to note that 25% of those who are started on TB treatment do not finish treatment because they feel it is not necessary.

This has contributed to Drug resistant TB or Multi-Drug resistant TB. Even if you have improved to whatever level, please finish your course. The following drugs are used for TB treatment: